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Imaging-Based Multiscale Models of the Respiratory System That Account for Regional Heterogeneity in Health and Disease

[+] Author Affiliations
S. Kabilan, D. R. Einstein, R. E. Jacob, J. P. Carson, A. P. Kuprat, K. R. Minard, R. A. Corley

Pacific Northwest National Laboratory, Richland, WA

Paper No. SBC2013-14636, pp. V01AT05A014; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Multiscale computational fluid dynamic (CFD) models are fast gaining importance in the field of respiratory systems modeling due to recent advancements in experimental and computational techniques. These models couple imaging-based, physiologically realistic, three-dimensional (3D) geometries to lower-dimensional ordinary differential equations (ODE) or partial differential equations (PDE) that represent the unseen lung. Local deviations from nominal heterogeneity and compliance in disease states such as emphysema and fibrosis have both important clinical and pathological implications. Hence, it is important to incorporate regional heterogeneity in the CFD models while modeling airflow characteristics, aerosol deposition, drug delivery, and risk assessment.

Copyright © 2013 by ASME



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