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Rheology Effects on Mucus Plug Rupture

[+] Author Affiliations
Yingying Hu, Shiyao Bian, Shuichi Takayama, James B. Grotberg

University of Michigan, Ann Arbor, MI

Marcel Filoche

University of Michigan, Ann Arbor, MIEcole Polytechnique, CNRS, Palaiseau, France

John C. Grotberg

University of Illinois at Chicago, Chicago, IL

Paper No. SBC2013-14507, pp. V01AT05A009; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Human respiratory mucus has non-Newtonian rheological properties of viscoelasticity, shear-thinning and yield stress. They play significant roles in mucus clearance by ciliary motion as well as cough [5,7,9]. Mucus is hypersecreted in such lung diseases as cystic fibrosis and asthma. Mucus hypersecretion damages mucus clearance mechanism [6], and more likely causes plugs to block partial or total airways [4].

Copyright © 2013 by ASME
Topics: Rheology , Rupture



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