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Advanced Human Coronary Plaque Wall Thickness Correlates Positively With Flow Shear Stress and Negatively With Plaque Wall Stress: An IVUS-Based FSI Study

[+] Author Affiliations
Dalin Tang

Worcester Polytechnic Institute, Worcester, MASoutheast University, China

Chun Yang

Worcester Polytechnic Institute, Worcester, MABeijing Normal University, Beijing, China

Joseph D. Petruccelli, Heng Zuo, Mehmet H. Kural, Kristen Billiar

Worcester Polytechnic Institute, Worcester, MA

Jie Zheng, Richard Bach, David Muccigrosso

Washington University, St. Louis, MO

Xueying Huang

Worcester Polytechnic Institute, Worcester, MAXiamen University, Xiamen, China

Deshan Yang

Washington University School of Medicine, St. Louis, MO

Paper No. SBC2013-14471, pp. V01AT04A015; 2 pages
doi:10.1115/SBC2013-14471
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Atherosclerotic plaque progression is believed to be associated with low and oscillating flow shear stress conditions [1–3]. In vivo image-based coronary plaque modeling papers are relatively rare because clinical recognition of vulnerable coronary plaques has remained challenging [3–4]. Samady et al. [3] published their seminal patient follow-up coronary plaque progression study and indicated that flow shear stress (FSS) was associated with plaque progression and remodeling. We have published results based on follow-up studies showing that advanced carotid plaque had positive correlation with flow shear stress and negative correlation with plaque wall stress (PWS) [4]. In this paper, patient-specific intravascular ultrasound (IVUS)-based coronary plaque models with fluid-structure interaction (FSI), on-site pressure and ex vivo biaxial mechanical testing of human coronary plaque material properties were constructed to obtain flow shear stress and plaque wall stress data from six patients to investigate possible associations between vessel wall thickness and both flow shear stress and plaque wall stress conditions.

Copyright © 2013 by ASME

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