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Estimation of Atherosclerotic Plaque Material Properties: A Mixed Method of Strain Imaging and Inverse Finite Element Analysis

[+] Author Affiliations
A. C. Akyildiz, L. Speelman, J. Wentzel, F. Gijsen

Erasmus Medical Center, Rotterdam, The Netherlands

H. H. G. Hansen, C. L. de Korte

University Nijmegen Medical Center, Nijmegen, The Netherlands

A. van der Steen

Erasmus Medical Center, Rotterdam, The NetherlandsInteruniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands

Paper No. SBC2013-14726, pp. V01AT03A005; 2 pages
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME


Atherosclerosis is a cardiovascular disease characterized by plaque formation in the vessel wall. Plaque rupture initiates thrombus formation and may lead to myocardial infarction, stroke and eventually, to sudden death [1]. A plaque ruptures when the mechanical stress in the plaque exceeds its strength. Thus, biomechanical models have a great potential to predict plaque rupture. For reliable prediction models, correct material properties of plaque components at large strains are prerequisite. However, the data available in literature are limited and show a wide range.

Copyright © 2013 by ASME



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