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Local Anisotropic Mechanical Behavior of Human Carotid Atherosclerotic Plaques: Characterization Using Indentation Test and Inverse Finite Element Analysis

[+] Author Affiliations
Chen-Ket Chai, Cees W. J. Oomens, Frank P. T. Baaijens

Eindhoven University of Technology, Eindhoven, The Netherlands

Ali C. Akyildiz, Lambert Speelman, Frank J. H. Gijsen, Aad van der Lugt

Erasmus Medical Center, Rotterdam, The Netherlands

Marc R. H. M. van Sambeek

Catharina Hospital Eindhoven, Eindhoven, The Netherlands

Paper No. SBC2013-14014, pp. V01AT03A001; 2 pages
doi:10.1115/SBC2013-14014
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

Atherosclerosis is a disorder of the arterial wall. The vessel wall is invaded by lipids and inflammatory cells which can lead to thickening of the arterial wall and eventually to formation of a vulnerable atherosclerotic plaque. Such a vulnerable plaque consists of intraplaque hemorrhage, inflammatory cells, a lipid rich necrotic core (LRNC) and a thin fibrous cap separating the thrombogenic LRNC from the blood stream. The thin fibrous cap is prone to rupture, which can cause thrombus formation and subsequent embolization of thrombus into distal vessels or acute occlusion. This is the major cause of stroke and myocardial infarction.

Copyright © 2013 by ASME

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