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Versatility of a Collagen Adaptation Model That Includes Strain-Dependent Degeneration and Cell Traction

[+] Author Affiliations
C. C. van Donkelaar, T. A. M. Heck, W. Wilson, J. Foolen, K. Ito

Eindhoven University of Technology, Eindhoven, The Netherlands

Paper No. SBC2013-14214, pp. V01AT02A003; 2 pages
doi:10.1115/SBC2013-14214
From:
  • ASME 2013 Summer Bioengineering Conference
  • Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments
  • Sunriver, Oregon, USA, June 26–29, 2013
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5560-7
  • Copyright © 2013 by ASME

abstract

The orientation of collagen fibers is essential for tissue mechanical functioning. Tissues are able to adapt this network to changes in the mechanical environment. Two mechanisms for this adaptation that have been proposed are cell-orientation dependent cell-traction (eg (6)), and strain-protected enzymatic collagen degradation (eg (11)). The premise is that these two mechanisms together are able to predict a transient and equilibrium responses of tissue adaptation to mechanical constraints. To evaluate this, they are captured in a numerical model and predictions are corroborated against distinct experimental observations. This abstract overviews the versatility of the model, using already presented (5) and new data.

Copyright © 2013 by ASME
Topics: Traction

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