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Microfluidic Device for Synthesis of Chitosan Nanoparticles

[+] Author Affiliations
Barbaros Cetin, Serdar Taze

Bilkent University, Ankara, Turkey

Mehmet D. Asik, S. Ali Tuncel

Hacettepe University, Ankara, Turkey

Paper No. FEDSM2013-16349, pp. V002T21A006; 7 pages
doi:10.1115/FEDSM2013-16349
From:
  • ASME 2013 Fluids Engineering Division Summer Meeting
  • Volume 2, Fora: Cavitation and Multiphase Flow; Fluid Measurements and Instrumentation; Microfluidics; Multiphase Flows: Work in Progress
  • Incline Village, Nevada, USA, July 7–11, 2013
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 978-0-7918-5558-4
  • Copyright © 2013 by ASME

abstract

Chitosan nanoparticles have a biodegradable, biocompatible, non-toxic structure, and commonly used for drug delivery systems. In this paper, simulation of a microfluidic device for the synthesis of chitosan nanoparticle is presented. The flow filed together with the concentration field within the microchannel network is simulated using COMSOL Multiphysics® simulation environment. Different microchannel geometries are analyzed, and the mixing performance of these configurations are compared. As a result, a 3D design for a microfluidics platform which includes four channel each of which performs the synthesis in parallel is proposed. Future research directions regarding the fabrication of the microfluidic device and experimentation phase are addressed and discussed.

Copyright © 2013 by ASME

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