Full Content is available to subscribers

Subscribe/Learn More  >

Scaling-Up Microchannel Emulsification Foreseeing Novel Bioactives Delivery Systems

[+] Author Affiliations
Marcos A. Neves, Mitsutoshi Nakajima

University of Tsukuba, Tsukuba, Ibaraki, Japan

Isao Kobayashi

National Food Research Institute, NARO, Tsukuba, Ibaraki, Japan

Paper No. ICNMM2013-73116, pp. V001T10A004; 7 pages
  • ASME 2013 11th International Conference on Nanochannels, Microchannels, and Minichannels
  • ASME 2013 11th International Conference on Nanochannels, Microchannels, and Minichannels
  • Sapporo, Japan, June 16–19, 2013
  • Conference Sponsors: Fluids Engineering Division, Heat Transfer Division
  • ISBN: 978-0-7918-5559-1
  • Copyright © 2013 by ASME


In the recent years, emulsification technologies that generate droplets individually have attracted a great deal attention in various fields, e.g., for chemicals, cosmetics, foods, and pharmaceuticals. Such drop-by-drop emulsification technologies include membrane emulsification using microporous membranes and microchannel (MC) emulsification, among others. The authors developed MC emulsification chips, consisting of parallel microgrooves or compactly arranged straight through-holes. Using this MC emulsification technique, the authors have evaluated the formulation a two-phase system consisting of size-controlled O/W emulsions loaded with bioactive molecules, such as β-carotene or γ-oryzanol, PUFAs or polyphenols. The MC emulsification process enabled the production of β-carotene-loaded O/W emulsions with average droplet size (dav) of 27.6 μm and coefficient of variation (CV) of 2.3% and γ-oryzanol-loaded droplets with dav of 28.8 μm and CV of 3.8%. The highly monodisperse O/W emulsions were physically stable during up 4 months storage in darkness at 5 °C. In addition, we investigated the formation characteristics of O/W emulsion droplets in the presence of electrolyte by MC emulsification using differently charged surfactants. Droplet formation was conducted by pressurizing a dispersed phase (refined soybean oil) through the MC silicon chip into a continuous phase containing 1.0 wt% of sodium dodecyl sulfate (SDS) or polyoxyethylene (20) sorbitan monolaurate (Tween 20), and an electrolyte (NaCl) (0–1.0 mol/L). Monodisperse O/W emulsions with an dav of 26 μm and a CV below 5% were produced when the NaCl concentration was lower than a threshold level that is 0.3 mol/L for SDS and 0.5 mol/L for Tween 20. The authors also developed a large MC emulsification device including a newly designed asymmetric MC array chip to realize the mass production of uniformly sized droplets on a liter per hour scale, so that satisfying the minimum droplet productivity needed for industrial-scale production. The large MC emulsification device has a potential droplet productivity exceeding several tons per year, which could satisfy a minimum industrial-scale production of monodisperse microdispersions containing emulsion droplets, microparticles, and microcapsules loaded with bioactive compounds. Such systems have as continuously increasing potential application in the formulation of functional foods, providing a good opportunity to improve the solubility of bioactive compounds, so that increasing their bioavailability.

Copyright © 2013 by ASME
Topics: Microchannels



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In