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Nanoparticle Redistribution During Magnetic Nanoparticle Hyperthermia: Multi-Physics Porous Medium Model Analyses

[+] Author Affiliations
Anilchandra Attaluri, Robert Ivkov

The Johns Hopkins University School of Medicine, Baltimore, MD

Ronghui Ma, Liang Zhu

University of Maryland, Baltimore County, Baltimore, MD

Paper No. IMECE2012-89486, pp. 1391-1395; 5 pages
doi:10.1115/IMECE2012-89486
From:
  • ASME 2012 International Mechanical Engineering Congress and Exposition
  • Volume 7: Fluids and Heat Transfer, Parts A, B, C, and D
  • Houston, Texas, USA, November 9–15, 2012
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4523-3
  • Copyright © 2012 by ASME

abstract

A coupled theoretical framework comprising a suspension of nanoparticles transport in porous media model and a heat transfer model is developed to address nanoparticle redistribution during heating. Nanoparticle redistribution in biological tissues during magnetic nanoparticle hyperthermia is described by a multi-physics model that consists of five major components: (a) a fully saturated porous media model for fluid flow through tissue; (b) nanoparticle convection and diffusion; (c) heat transfer model based on heat generation by local nanoparticle concentration; (d) a model to predict tissue thermal damage and corresponding change to the porous structure; and (e) a nanoparticle redistribution model based on the dynamic porosity and diffusion diffusivity. The integrated model has been used to predict the structural damage in porous tumors and its effect on nanoparticle-induced heating in tumors. Thermal damage in the vicinity of the tumor center that is predicted by the Arrhenius equation increases from 14% with 10 minutes of heating to almost 99% after 20 minutes. It then induces an increased tumor porosity that increases nanoparticle diffusivity by seven-fold. The model predicts thermal damage induced by nanoparticle redistribution increases by 20% in the radius of the spherical tissue region containing nanoparticles. The developed model has demonstrated the feasibility of enhancing nanoparticle dispersion from injection sites using targeted thermal damage.

Copyright © 2012 by ASME

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