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The Effect of Feedback on Alternans Formation in the Heart

[+] Author Affiliations
Stephen D. McIntyre, Yoichiro Mori, Elena G. Tolkacheva

University of Minnesota, Minneapolis, MN

Paper No. DSCC2012-MOVIC2012-8646, pp. 585-589; 5 pages
  • ASME 2012 5th Annual Dynamic Systems and Control Conference joint with the JSME 2012 11th Motion and Vibration Conference
  • Volume 1: Adaptive Control; Advanced Vehicle Propulsion Systems; Aerospace Systems; Autonomous Systems; Battery Modeling; Biochemical Systems; Control Over Networks; Control Systems Design; Cooperative and Decentralized Control; Dynamic System Modeling; Dynamical Modeling and Diagnostics in Biomedical Systems; Dynamics and Control in Medicine and Biology; Estimation and Fault Detection; Estimation and Fault Detection for Vehicle Applications; Fluid Power Systems; Human Assistive Systems and Wearable Robots; Human-in-the-Loop Systems; Intelligent Transportation Systems; Learning Control
  • Fort Lauderdale, Florida, USA, October 17–19, 2012
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-4529-5
  • Copyright © 2012 by ASME


A beat-to-beat alternation in the duration of the action potential (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation (VF) in the whole heart. A common technique for the prediction of alternans uses the restitution curve, the nonlinear functional relationship between the APD and the preceding diastolic interval (DI). It was proposed that alternans appears when the magnitude of the slope of the restitution curve exceeds one, known as the restitution hypothesis. However, this restitution hypothesis was derived in the presence of feedback, i.e. the partial dependence of the DI on the immediate preceding APD. Physiologically, the heart rate exhibits substantial variations, known as heart rate variability (HRV), which might affect the feedback relationship. In this manuscript, we aim to investigate the effect of feedback on alternans formation in the heart.

Copyright © 2012 by ASME
Topics: Feedback



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