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Impulsive Predictive Control of T1DM Glycemia: An In-Silico Study

[+] Author Affiliations
Marzia Cescon, Meike Stemmann, Rolf Johansson

Lund University, Lund, Sweden

Paper No. DSCC2012-MOVIC2012-8550, pp. 319-326; 8 pages
  • ASME 2012 5th Annual Dynamic Systems and Control Conference joint with the JSME 2012 11th Motion and Vibration Conference
  • Volume 1: Adaptive Control; Advanced Vehicle Propulsion Systems; Aerospace Systems; Autonomous Systems; Battery Modeling; Biochemical Systems; Control Over Networks; Control Systems Design; Cooperative and Decentralized Control; Dynamic System Modeling; Dynamical Modeling and Diagnostics in Biomedical Systems; Dynamics and Control in Medicine and Biology; Estimation and Fault Detection; Estimation and Fault Detection for Vehicle Applications; Fluid Power Systems; Human Assistive Systems and Wearable Robots; Human-in-the-Loop Systems; Intelligent Transportation Systems; Learning Control
  • Fort Lauderdale, Florida, USA, October 17–19, 2012
  • Conference Sponsors: Dynamic Systems and Control Division
  • ISBN: 978-0-7918-4529-5
  • Copyright © 2012 by ASME


The most widespread approach for glycemic control in diabetic patients is the so-called basal-bolus insulin regimen, comprising insulin injections at meal times, correction doses in hyperglycemia and compensatory carbohydrate in case of insulin-induced hypoglycemia. The present contribution represents an attempt at implementing such a strategy on a population of 4 virtual, i.e., in-silico, T1DM patients. Low-order physiologically sound transfer function models were estimated for each of the in-silico subjects from simulated data and exploited in an optimization-based control algorithm, the objective being sustainment of glycemia in the near-normal range (70–180 [mg/dL]).

Copyright © 2012 by ASME



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