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Continuous Positive Airway Pressure Impacts Cerebral Blood Flow and Cerebrospinal Fluid Motion: A Phase Contrast MRI Study

[+] Author Affiliations
Benedict D. Anthikat-Albert

Kungliga Tekniska Hogskolan, Stockholm, Sweden

Theresia I. Yiallourou, Nikolaos Stergiopulos, Bryn A. Martin

École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Jose Haba-Rubio, Raphael Heinzer, Eleonora Fonari, Nicolas Chevrey

Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

Francesco Santini

University of Basel Hospital, Basel, Switzerland

Paper No. SBC2012-80683, pp. 569-570; 2 pages
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME


The physiological impacts of continuous positive airway pressure (CPAP) are not yet fully understood. In this study we developed an MRI protocol to assess the impact of CPAP on cerebral hemodynamics and cerebrospinal fluid (CSF) hydrodynamics in the upper cervical spine. MRI measurements were obtained on 14 healthy male subjects. The preliminary results indicated that the CSF pulsation decreased and venous outflow was altered with CPAP usage in comparison to the baseline values. Cerebral arterial flow was not impacted by CPAP usage. These findings support the hypothesis that the CSF system can act to dampen cerebral blood flow (CBF) pulsations.

Copyright © 2012 by ASME



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