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Quantitative Mapping of Local Mechanical Properties of Living Cells at Near-Physiological Conditions Using Multi-Harmonic Atomic Force Microscopy

[+] Author Affiliations
Alexander Cartagena, Wen-Horng Wang, Robert L. Geahlen, Arvind Raman

Purdue University, West Lafayette, IN

Paper No. SBC2012-80837, pp. 523-524; 2 pages
doi:10.1115/SBC2012-80837
From:
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME

abstract

Measurements of local nanomechanical properties of living cells recently have become extremely important for the cellular biology and biomechanics communities [1]. The measurement of progressive variations in viscoelastic properties of living cells in their native physiological liquid environments can provide significant insight to the mechanistic processes underpinning morphogenesis, mechano-transduction, motility, metastasis, aging, etc. Atomic Force Microscopy (AFM) based biomechanical assays have the unique advantage of resolving/mapping spatially the local nanomechanical properties over the cell surface. However current methods using standard force-volume, force displacement curves [2–3] are very low resolution and low speed making them completely incompatible for biomechanical assays of living cells.

Copyright © 2012 by ASME

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