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Regional Biomechanical and Microstructural Alterations of the Ovine Main Pulmonary Artery During Postnatal Growth

[+] Author Affiliations
Bahar Fata, Christopher A. Carruthers, Gregory A. Gibson, Simon C. Watkins

University of Pittsburgh, Pittsburgh, PA

Danielle Gottlieb, John E. Mayer

Harvard Medical School, Boston, MA

Michael S. Sacks

University of Texas, Austin, TX

Paper No. SBC2012-80085, pp. 477-478; 2 pages
doi:10.1115/SBC2012-80085
From:
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME

abstract

It has been estimated that worldwide 600,000 babies are born annually with significant congenital heart disease (1). Congenital heart and related vascular defects cause increased flow and pulmonary pressure leading to unfavorable vascular remodeling that results in pulmonary arterial hypertension (1). Developing tissue engineered replacements that mimic the growth and remodeling behavior of native tissue is the optimal approach in treatment of congenital arterial anomalies. The understanding of the underlying mechanisms leading to pulmonary arterial hypertension as well as replicating native pulmonary artery functionality in engineered replacements requires knowledge of native tissue mechanics and growth behavior. In the present study, we report novel information on the changes in the structure-mechanics behavior of the growing pulmonary artery.

Copyright © 2012 by ASME

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