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Lineage Tracing Reveals a New Model for Tendon Growth and Elongation During Development

[+] Author Affiliations
Alice H. Huang, Spencer S. Watson, Ronen Schweitzer

Shriners Hospital for Children, Portland, OR

Paper No. SBC2012-80915, pp. 439-440; 2 pages
doi:10.1115/SBC2012-80915
From:
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME

abstract

Tendons are dense, fibrous tissues connecting muscle to bone, and their primary function is to transmit muscle forces to the appropriate skeletal elements, thereby enabling movement. In the limb, flexion and extension of the hand (autopod) and wrist are controlled by long tendons that insert into muscles in the arm (zeugopod) [1]. Although tendons are critically important in mediating joint movement, the cellular and molecular events underlying tendon formation remain largely unknown. Using the transcription factor Scleraxis (Scx), which labels all tendon progenitors, we previously showed that in the mouse limb bud, Scx-expressing tendon progenitors are first induced in the mesenchyme underneath the ectoderm at E10.5; at E12.5, progenitors are loosely organized between the cartilage condensations and developing muscles, condensing to form distinct tendons by E13.5 [2]. By E14.5, limb tendon patterning is largely complete, with continued elongation and deposition of matrix from this stage onward.

Copyright © 2012 by ASME
Topics: Elongation , Tendons

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