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Finite Element Modelling of In Vitro Articular Cartilage Wear in the Patellofemoral Joint

[+] Author Affiliations
Lingmin Li, Benjamin J. Fregly

University of Florida, Gainesville, FL

Shantanu Patil, Nick Steklov, Darryl D. D’Lima

Shiley Center for Orthopaedic Research & Education, La Jolla, CA

Won Bae, Robert L. Sah

University of California, San Diego, La Jolla, CA

Paper No. SBC2012-80043, pp. 163-164; 2 pages
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME


The mechanism by which altered knee joint motions and loads (e.g., following anterior cruciate ligament (ACL) injury) contribute to the development of knee osteoarthritis (OA) is not well understood. One mechanobiological hypothesis is that articular cartilage degradation is initiated when altered knee kinematics increase loading on certain regions of the articular surfaces and decrease loading on other regions [1]. If homeostatic loading conditions vary from region to region, then load changes induced by altered kinematics could initiate cartilage degradation in a site-specific manner. This hypothesis is attractive from a computational simulation perspective since it is based on mechanical factors that lend themselves well to physical modeling. If computational simulations could predict the knee OA development process, then they could potentially be used to facilitate the design of new or improved treatments for the disease.

Copyright © 2012 by ASME



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