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Injectable and Photocrosslinkable Laminin Functionalized Biomaterials for Intervertebral Disc Regeneration

[+] Author Affiliations
Aubrey T. Francisco, Robert J. Mancino, Claire G. Jeong, Robby D. Bowles, Stephen L. Craig

Duke University, Durham, NC

Isaac O. Karikari

Duke University Medical Center, Durham, NC

Lori A. Setton

Duke University, Durham, NCDuke University Medical Center, Durham, NC

Paper No. SBC2012-80660, pp. 1145-1146; 2 pages
doi:10.1115/SBC2012-80660
From:
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME

abstract

Biological and anatomical changes of intervertebral disc (IVD) degeneration frequently occur in the nucleus pulposus (NP) [1]. Changes in NP matrix composition coincide with the loss of a distinct notochord derived cell population [2],[3], which may have the potential to generate or maintain a functional NP-like matrix. Immature NP cells reside in an environment rich in laminin and express specific laminin-binding receptors [4],[5]. Additionally, NP cells attach in higher numbers to laminins as compared to cells isolated from other regions of the IVD [6]. Our initial work demonstrated that matrix protein and stiffness modulate NP cell-cell interactions upon surfaces [7], with results that suggest soft, laminin-functionalized hydrogels may be useful for promoting an NP-like cell phenotype.

Copyright © 2012 by ASME

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