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Enhancing the Mechanical Properties of Articular Cartilage Through Enzyme-Mediated Collagen Crosslinking as Regulated by Low Oxygen Tension

[+] Author Affiliations
Eleftherios A. Makris, Jerry Hu, Kyriacos A. Athanasiou

University of California, Davis, Davis, CA

Paper No. SBC2012-80603, pp. 1021-1022; 2 pages
  • ASME 2012 Summer Bioengineering Conference
  • ASME 2012 Summer Bioengineering Conference, Parts A and B
  • Fajardo, Puerto Rico, USA, June 20–23, 2012
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4480-9
  • Copyright © 2012 by ASME


The poor ability of articular cartilage to repair following disease and injury makes the tissue a key target for reparative and regenerative medicine strategies. It has been shown that human knee joint resides under hypoxic conditions. Oxygen tension in healthy human synovium is between 7 and 11% and in articular cartilage may therefore be as low as 1–2.5% [1].

Copyright © 2012 by ASME



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