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Nanodiamond Reinforced PLLA Nanocomposites for Bone Tissue Engineering

[+] Author Affiliations
Qingwei Zhang, Yury Gogotsi, Peter I. Lelkes, Jack G. Zhou

Drexel University, Philadelphia, PA

Paper No. MSEC2012-7393, pp. 885-889; 5 pages
doi:10.1115/MSEC2012-7393
From:
  • ASME 2012 International Manufacturing Science and Engineering Conference collocated with the 40th North American Manufacturing Research Conference and in participation with the International Conference on Tribology Materials and Processing
  • ASME 2012 International Manufacturing Science and Engineering Conference
  • Notre Dame, Indiana, USA, June 4–8, 2012
  • Conference Sponsors: Manufacturing Engineering Division
  • ISBN: 978-0-7918-5499-0
  • Copyright © 2012 by ASME

abstract

Nanodiamond (ND) is an attractive nanomaterial for reinforcement of biopolymers due to the ND’s superior mechanical and chemical properties, and low biotoxicity. A novel composite material has been produced for bone scaffolds utilizing the biodegradable polymer poly(L-lactic acid) (PLLA) and octadecylamine-functionalized nanodiamond (ND-ODA). Composites were prepared by admixing to a PLLA/chloroform solution chloroform suspension of ND-ODA in concentration range of 0–10% (w/w). The dispersion of ND-ODA evaluated by transmission electron microscopy (TEM) shows uniform distribution of ND-ODA in PLLA matrix. The composites were characterized by differential scanning calorimetry (DSC). DSC analysis of the composites showed no significant thermal behavior changes with the addition of ND-ODA into the polymer. Biomineralization test shows that ND-ODA can enhance the mineral deposition on scaffolds. Improved mechanical properties and good biocompatibility with enhanced biomineralization combined suggest that ND-ODA/PLLA might have potential applications for bone tissue engineering.

Copyright © 2012 by ASME
Topics: Bone , Nanocomposites

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