0

Full Content is available to subscribers

Subscribe/Learn More  >

Design of Tissue-Engineered Leaflet Shape for the Ovine Pulmonary Valve Single Leaflet Replacement Surgery

[+] Author Affiliations
Rong Fan, Christopher M. Hobson, William R. Wagner, Michael S. Sacks

University of Pittsburgh, Pittsburgh, PA

Ahmed Bayoumi, John E. Mayer, Jr.

Harvard Medical School, Boston, MA

Paper No. SBC2011-53949, pp. 775-776; 2 pages
doi:10.1115/SBC2011-53949
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

Pulmonary valve (PV) replacement surgery is a treatment option for patients with a congenitally defective pulmonary outflow track. A tissue engineered pulmonary valve (TEPV) is a potential approach to serve as a replacement pediatric heart valve that has the potential for somatic growth. The single leaflet replacement surgical model can assist in assessing candidate biomaterials responses to in-vivo function. However, an empirically determined unloaded leaflet shape may result in abnormal valve function due to incomplete coaptation of leaflets and asymmetric stress distributions. Thus, to determine the final deformed shape of an engineered scaffold replacement PV leaflet under transvalvular pressure the following key factors must be determined: the scaffold anisotropic mechanical properties, optimal thickness, and the exact initial leaflet shape. We have used electrospun poly (ester urethane) ureas (ES-PEUU) scaffolds since they exhibit mechanical properties very similar to the native PV [1]. In this work we present a design framework of the optimal leaflet shape determination utilizing a single sheet of ES-PEUU for single leaflet replacement surgery via finite element (FE) simulation. The mechanical properties of ES-PEUU scaffold for leaflet replacement were obtained from biaxial in-plane tension and three-point bending flexural deformation experiments. Generalized Fung-type hyperelastic constitutive model [2] was implemented into a commercial FE software package to simulate the mechanical behavior of ES-PEUU scaffolds. By perturbing the initial shape of leaflet and simulating its quasi-static deformation under PV diastolic loading, the optimal shape of unloaded leaflet can be determined by comparing the deformed shape of leaflet obtained from FE simulation of TEPV with the one from microCT scan of a native ovine PV.

Copyright © 2011 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In