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Biomechanical and Microstructural Analysis of Wildtype (C57BL6) Mouse Aorta

[+] Author Affiliations
Darren Haskett, Greg Johnson, Mohamad Azhar, Jonathan Vande Geest

University of Arizona, Tucson, AZ

Paper No. SBC2011-53729, pp. 67-68; 2 pages
doi:10.1115/SBC2011-53729
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

It is generally accepted that the formation of an aneurysm in the infrarenal aorta is a complex and multi-factorial disease, however little is known about how biomechanical factors may play a role in the progression of aneurysmal disease. Although it is known that human aneurysmal tissue is remodeled in the disease process [1] and that such reorganization leads to altered function [2], the underlying mechanisms by which such changes remains an important unanswered question in the literature. The purpose of this study is to develop a means for determining the biomechanical alterations that occur within the aorta to better understand aneurysmal disease progression.

Copyright © 2011 by ASME
Topics: Biomechanics , Aorta

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