Full Content is available to subscribers

Subscribe/Learn More  >

A Coupled Computational Framework for Multiscale Modeling and Optimization of Single Ventricle Repair

[+] Author Affiliations
Alison L. Marsden, Mahdi Esmaily Moghadam, Weiguang Yang

UCSD, La Jolla, CA

Alessia Baretta, Chiara Corsini, Francesco Migliavacca

Politecnico di Milano, Milan, Italy

Irene Vignon-Clementel

INRIA Paris-Rocquencourt, Le Chesnay, France

Jeffrey Feinstein

Lucile Packard Children’s Hospital, Palo Alto, CA

Tain-Yen Hsia

Great Ormond Street Hospital for Children, London, UK

Paper No. SBC2011-53759, pp. 519-520; 2 pages
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME


Multiscale modeling provides a means to relate global response to local changes in geometry and hemodynamics in the circulatory system. In this work, we couple a customized lumped parameter network (LPN) representing the whole circulation (heart, systemic and pulmonary circulations) to three-dimensional finite element models of two stages of the single ventricle surgical pathway. A fully-coupled closed-loop approach is employed using custom codes with Neumann boundary conditions at the inlets and outlets. The methodology is described, and applied to two stages of single ventricle repair to illustrate its utility: the BT-shunt (stage 1), and the Fontan surgery (stage 3).

Copyright © 2011 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In