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A Coupled Computational Framework for Multiscale Modeling and Optimization of Single Ventricle Repair

[+] Author Affiliations
Alison L. Marsden, Mahdi Esmaily Moghadam, Weiguang Yang

UCSD, La Jolla, CA

Alessia Baretta, Chiara Corsini, Francesco Migliavacca

Politecnico di Milano, Milan, Italy

Irene Vignon-Clementel

INRIA Paris-Rocquencourt, Le Chesnay, France

Jeffrey Feinstein

Lucile Packard Children’s Hospital, Palo Alto, CA

Tain-Yen Hsia

Great Ormond Street Hospital for Children, London, UK

Paper No. SBC2011-53759, pp. 519-520; 2 pages
doi:10.1115/SBC2011-53759
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

Multiscale modeling provides a means to relate global response to local changes in geometry and hemodynamics in the circulatory system. In this work, we couple a customized lumped parameter network (LPN) representing the whole circulation (heart, systemic and pulmonary circulations) to three-dimensional finite element models of two stages of the single ventricle surgical pathway. A fully-coupled closed-loop approach is employed using custom codes with Neumann boundary conditions at the inlets and outlets. The methodology is described, and applied to two stages of single ventricle repair to illustrate its utility: the BT-shunt (stage 1), and the Fontan surgery (stage 3).

Copyright © 2011 by ASME

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