0

Full Content is available to subscribers

Subscribe/Learn More  >

Modeling the Inflation Response of C57BL/6 Mouse Sclera

[+] Author Affiliations
Kristin M. Myers

Columbia University, New York, NY

Thao D. Nguyen

Johns Hopkins University, Baltimore, MD

Paper No. SBC2011-53181, pp. 429-430; 2 pages
doi:10.1115/SBC2011-53181
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

Small rodent models have become increasingly useful to investigate how the mechanical properties of soft tissues may influence disease development. These animal models allow access to aged, diseased, or genetically-altered tissue samples, and through comparisons with wild-type or normal tissue it can be explored how each of these variables influence tissue function. The challenges to deriving meaningful material parameters for these small tissue samples include designing physiologically-relevant mechanical testing protocols and interpreting the experimental load-displacement data in an appropriate constitutive framework to quantify material parameters. This study was motivated by determining the possible role of scleral material properties in the development of glaucomatous damage to the retinal ganglion cells (RGC). Glaucoma is one of the leading causes of blindness in the United States and in the world with an estimate of 60 million people affected by this year [1]. Through exploring mouse models, the overall goal of our work is to determine the role of scleral material properties and scleral tissue microstructure in the pathogenesis of glaucoma.

Copyright © 2011 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In