Full Content is available to subscribers

Subscribe/Learn More  >

Effect of ST2, a Fragment of ADAMTS13, on Cleavage of Von Willebrand Factor

[+] Author Affiliations
Jin-Yu Shao, Yingchen Ling, J. Evan Sadler, Elaine M. Majerus

Washington University in Saint Louis, Saint Louis, MO

Paper No. SBC2011-53317, pp. 351-352; 2 pages
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME


Von Willebrand Factor (VWF) is a multimeric plasma glycoprotein that mediates platelet adhesion and aggregation, a process critical for both hemostasis and thrombosis. Under normal conditions, VWF binds to platelets at sites of vascular injury or damage, leading to blood clot formation and wound healing. VWF contains four types of repeating domains in the following sequence: D1-D2-D’-D3-A1-A2-A3-D4-B1-B2-B3-C1-C2-CK (CK: cystine knot). It is synthesized and secreted into plasma by endothelial cells and megakaryocytes. Many newly-secreted VWF multimers are huge in size, thus they are termed ultra-large VWF (ULVWF). ULVWF is thrombogenic, so it is reduced to smaller VWF multimers by ADAMTS13, a metalloprotease that cleaves the Tyr1605-Met1606 bond in the A2 domain of VWF. Proper ULVWF cleavage and subsequent VWF cleavage result in appropriate size distribution of VWF in plasma, which is required for its hemostatic function. On the one hand, insufficient cleavage of ULVWF leads to thrombotic thrombocytopenic purpura (TTP), a disease characterized by microvascular thrombosis; on the other hand, excessive cleavage of VWF leads to Von Willebrand disease (VWD), a potentially-fatal bleeding disorder manifested by lack of large VWF multimers in plasma [1]. Therefore, understanding VWF cleavage by ADAMTS13 is crucial for understanding VWF function and its related diseases.

Copyright © 2011 by ASME



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In