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Geometric and Hemodynamic Evaluation of 3-Dimensional Reconstruction Techniques for the Assessment of Coronary Artery Wall Shear Stress in the Setting of Clinical Disease Progression

[+] Author Affiliations
Lucas H. Timmins, John N. Oshinski

Georgia Institute of Technology, Atlanta, GAEmory University School of Medicine, Atlanta, GA

Jin Suo, Don P. Giddens

Georgia Institute of Technology, Atlanta, GA

Parham Eshtehardi, Saurabh S. Dhawan, Michael C. McDaniel, Habib Samady

Emory University School of Medicine, Atlanta, GA

Paper No. SBC2011-53528, pp. 21-22; 2 pages
doi:10.1115/SBC2011-53528
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

Myocardial infarction and sudden cardiac death are usually due to the rapid progression of previously non-flow limiting atherosclerotic plaques that transform to an unstable (i.e., vulnerable) phenotype. Despite considerable advances in medical therapies and treatment modalities for coronary artery disease (CAD), there is no accurate method to predict the site of abrupt lesion progression that can lead to an acute coronary event. Wall shear stress (WSS) has not only been implicated in the development of CAD, but also in its rapid progression [1]. Recent data from our laboratory indicates significant plaque progression in areas of low WSS (<10 dynes/cm2), plaque regression in regions of physiologic WSS (10–25 dynes/cm2), and phenotypic transformation towards an unstable lesion in regions of high WSS (>25 dynes/cm2) [2].

Copyright © 2011 by ASME

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