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Design Optimization of Rotary Blood Pumps: Alternatives to Anticoagulation Therapy

[+] Author Affiliations
Gaurav Girdhar, Michalis Xenos, Wei-Che Chiu, Yared Alemu, Jolyon Jesty, Shmuel Einav, Danny Bluestein

Stony Brook University, Stony Brook, NY

Bryan Lynch

MicroMed Cardiovascular Inc., Houston, TX

Marvin Slepian

University of Arizona, Tucson, AZ

Paper No. SBC2011-53171, pp. 173-174; 2 pages
doi:10.1115/SBC2011-53171
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

Mechanical circulatory support (MCS) devices such as the ventricular assist devices (VADs) provide life saving short-term bridge-to-transplant solutions (1) to a large proportion of patients who suffer from chronic heart failure. Although hemodynamically efficient, such devices are burdened with high incidence of thromboembolic events due to non-physiological flow past constricted geometries where platelets (the principal cellular clotting elements in blood) are exposed to elevated shear stresses and exposure times (2) — requiring mandatory anticoagulation. We recently developed an optimization methodology — Device Thrombogenicity Emulator (DTE)(3) — that integrates device specific hemodynamic stresses (from numerical simulations) with experimental measurements of platelet activation. The DTE was successfully applied by our group to measure / optimize the thromboresistance of mechanical heart valves (MHV) (3, 4).

Copyright © 2011 by ASME

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