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Functionalization of Electrospun Poly (Caprolactone) to Achieve Enhanced Cell Attachment

[+] Author Affiliations
Manisha Jassal, Shawn M. Regis, Sankha Bhowmick

University of Massachusetts Dartmouth, North Dartmouth, MA

Paper No. SBC2011-53509, pp. 139-140; 2 pages
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME


The covalent immobilization of various compounds onto functionalized polymer surfaces has been an area of interest to the researchers in the past decade. Methods that can be used to alter the surface properties of materials to improve performance, biocompatibility or to achieve certain desired effects are a key to continued development of these materials [1]. The artificial scaffolds trying to mimic the architecture of natural human tissues at nanoscale may lead to successful implants within the body [2]. Among various nano-scaled materials, nano fibers produced by electrospinning process offer advantages as comparatively low cost, production of continuous fibers, feasibility of complex and seamless three dimensional shapes and many more. In the present work, polycaprolactone nanofibers were generated by electrospinning process and the scaffolds were functionalized in two different ways i.e. by amination followed by subsequent RGD immobilization and hydrolysis. Thereafter, fibroblast cells behavior was studied on functionalized scaffolds.

Copyright © 2011 by ASME



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