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Three Dimensional Cellular Loading and Average Microstructural Tissue Response Using Single and Three Cell Models

[+] Author Affiliations
Jason Halloran, Scott Sibole, Ahmet Erdemir

Cleveland Clinic, Cleveland, OH

Paper No. SBC2011-53663, pp. 1253-1254; 2 pages
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME


Finite element analysis of single cells embedded in an extracellular matrix have been used widely to provide new insights into the cellular loading in cartilage [1] and meniscus [2]. Deformations derived from a homogeneous tissue model are generally used to drive simulations using microstructural representations. Implicit in this setup is the assumption of the equivalence of macrostructural (tissue) constitutive response and average stress-strain response of the microstructural (cellular) model. Higher cell densities within tissue volume [3] may increase the uncertainty introduced by this assumption and may also influence how macroscopic loads are transferred to the cells. We have previously shown, albeit with a two-dimensional simulation, the potential mismatches in such variables for increasing strain level and cell density, specifically for no cell, one, and three cell representations [4]. Hence, the objective of this study was to quantify the differences between the overall response and cellular deformation in three-dimensional nonlinearly elastic microstructural cartilage models embedded with either one or three cells. Multiscale coupling approaches targeting prediction of cell deformations from tissue and/or organ level loading will likely benefit from this investigation while balancing computational demand with accuracy requirements.

Copyright © 2011 by ASME



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