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Effect of In Vivo Physical Interaction of the Ascending Aorta and Main Pulmonary Artery on Postnatal Surface Growth Patterns in Ovine

[+] Author Affiliations
Bahar Fata, Michael S. Sacks

University of Pittsburgh, Pittsburgh, PA

Danielle Gottlieb, John E. Mayer

Children’s Hospital of Boston/Harvard Medical School, Boston, MA

Paper No. SBC2011-53978, pp. 1203-1204; 2 pages
doi:10.1115/SBC2011-53978
From:
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME

abstract

Congenital abnormalities of the main pulmonary artery (MPA) and ascending aorta (AA) often necessitate surgical repair or the use of a valved conduit replacement, requiring multiple re-interventions due to regurgitation or failure of the prosthetic conduit. In recent years there has been a growing interest in the development of a living autologous tissue graft that could address the critical need for growing substitutes in the repair of congenital cardiovascular defects [1]. Regardless of the particulars of the therapeutic approach, the detailed growth characteristics of the native artery is required to establish the baseline dimensional changes post-implantation. During normal embryogenesis the Truncus Arteriosus begins to split and form into the anterior pulmonary artery and the posterior aorta [2]. Due to their common embryologic origin from a single outflow tract, there are disease conditions that originate in one artery and eventually affect both arteries [3]. Therefore, the postnatal growth deformation of both the MPA and AA was computed to quantify the effects of the mechanical association of these two arteries.

Copyright © 2011 by ASME

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