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The Role of Cells in Collagen Modeling in Tissue Engineered Constructs: A Theoretical Framework

[+] Author Affiliations
Ana L. F. Soares, Marijke A. A. van Vlimmeren, Cees W. J. Oomens, Frank P. T. Baaijens

Eindhoven University of Technology, Eindhoven, The Netherlands

Paper No. SBC2011-53263, pp. 1189-1190; 2 pages
  • ASME 2011 Summer Bioengineering Conference
  • ASME 2011 Summer Bioengineering Conference, Parts A and B
  • Farmington, Pennsylvania, USA, June 22–25, 2011
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-5458-7
  • Copyright © 2011 by ASME


Mechanical loading protocols in tissue engineering (TE) aim to improve the deposition of a properly organized collagen fiber network. These conditioning protocols can result in tissue compaction [1], which may lead to loss of functionality of the tissue construct. A balance between the collagen deposition and compaction is desirable, yet difficult to achieve, due to the nonlinear coupling between mechanical loading, collagen modeling and compaction.

Copyright © 2011 by ASME



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