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Effects of Tensile Stimulation on Gene Expression and In Vitro Stiffness of Murine Tissue Engineered Constructs

[+] Author Affiliations
Nathaniel A. Dyment, Kumar Chokalingam, Cynthia Gooch, Jason T. Shearn, David L. Butler

University of Cincinnati, Cincinnati, OH

Amanda Shoemaker, Christopher Wylie

Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH

Paper No. SBC2010-19120, pp. 963-964; 2 pages
doi:10.1115/SBC2010-19120
From:
  • ASME 2010 Summer Bioengineering Conference
  • ASME 2010 Summer Bioengineering Conference, Parts A and B
  • Naples, Florida, USA, June 16–19, 2010
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4403-8
  • Copyright © 2010 by ASME

abstract

Tendon and ligament injuries account for ∼45% of the 32.8 million musculoskeletal injuries that occur in the US every year [1]. Natural adult healing of these injuries is often inadequate and can diminish the quality of life for the patient. Tissue engineers, including those in our lab, have attempted to augment the natural healing process through a variety of methods including mechanical simulation of tissue engineered constructs (TECs) to improve repair outcome [2]. Building on our successes with mechanical stimulation, we now seek to modulate genes expressed during normal development in our TECs in culture to improve repair outcome in vivo. An initial step in this process is to determine if our TECs express genes within pathways of normal tendon development.

Copyright © 2010 by ASME

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