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Development and Biomechanical Characterization of a Novel Bilayer Vascular Graft

[+] Author Affiliations
Krishna Madhavan

University of Colorado at Boulder, Boulder, CO

Walter Bonani

University of Colorado at Boulder, Boulder, COUniversity of Trento, Trento, Italy

Craig Lanning

University of Colorado at Denver, Aurora, CO

Wei Tan

University of Colorado at Boulder, Boulder, COUniversity of Colorado at Denver, Aurora, CO

Paper No. SBC2010-19613, pp. 783-784; 2 pages
doi:10.1115/SBC2010-19613
From:
  • ASME 2010 Summer Bioengineering Conference
  • ASME 2010 Summer Bioengineering Conference, Parts A and B
  • Naples, Florida, USA, June 16–19, 2010
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4403-8
  • Copyright © 2010 by ASME

abstract

Vascular grafts are currently used to treat cardiovascular diseases such as arthrosclerosis by bypass surgery and as vascular access in hemodialysis [1]. There are a number of types of grafts including autologous vessels (such saphenous vein), synthetic grafts (such as expanded polytetrafluoroethylene) and tissue engineered blood vessels. Currently synthetic grafts are most commonly used as blood vessel replacements and there are a number of problems associated with them. One main impediment is that these grafts are not suitable for small-diameter (less than 6mm) vessel replacement [1, 2], due to high occlusion rates. The major concern over the other alternatives such as autologous vessels and tissue engineered products is their availability. Thus, new approaches to constructing biomimetic small-diameter blood vessel equivalents, that are immediately available, may address the unmet demand in this area. Therefore, we have designed a novel bilayer vascular construct which is made up of a nanofibrous intimal-equivalent as thromboresistant vessel lumen and a mimetic extracellular matrix (ECM) as medial-equivalent for smooth muscle cells (SMC) from native artery to invade and remodel the ECM.

Copyright © 2010 by ASME

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