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Endothelial Cell Permeability and Alignment Quantification Under Shear Flow

[+] Author Affiliations
Lucas Ting, Jessica Jahn, Nathan Sniadecki

University of Washington, Seattle, WA

Paper No. SBC2010-19705, pp. 581-582; 2 pages
doi:10.1115/SBC2010-19705
From:
  • ASME 2010 Summer Bioengineering Conference
  • ASME 2010 Summer Bioengineering Conference, Parts A and B
  • Naples, Florida, USA, June 16–19, 2010
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4403-8
  • Copyright © 2010 by ASME

abstract

Atherosclerosis develops when a breach in the protective endothelium allows macrophages and fatty lipids to enter into the intima. Atherosclerotic plaque material can harden the vessel or constrict blood flow through the vessel. In some cases, the plaque can detach and initiate a cardiac event (1). Hemodynamic shear can act as a mechanical factor that regulates the endothelial barrier by initiating a cellular mechanotransduction response that remodels the structure of individual endothelial cells (2).

Copyright © 2010 by ASME

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