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Quantitative, 3-D Imaging to Co-Localize Bone and Vasculature Tissues During Bone Healing

[+] Author Affiliations
Elise F. Morgan, Billy Andre, Daniel E. Hogan, Jr., Bader A. Al-Awadhi, Louis C. Gerstenfeld

Boston University, Boston, MA

Paper No. SBC2010-19100, pp. 53-54; 2 pages
doi:10.1115/SBC2010-19100
From:
  • ASME 2010 Summer Bioengineering Conference
  • ASME 2010 Summer Bioengineering Conference, Parts A and B
  • Naples, Florida, USA, June 16–19, 2010
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4403-8
  • Copyright © 2010 by ASME

abstract

Successful bone repair requires reestablishment of a blood supply at the injury site [1]. However, despite convincing evidence of the close relationship between angiogenesis and osteogenesis during bone healing, little is known about the spatial correspondence between these two processes. This paucity of information hampers understanding of the mechanisms regulating osteogenesis during bone healing and of how molecular communication between endothelial cells and osteoblasts mediates the restoration of mechanical function.

Copyright © 2010 by ASME

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