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Effect of Ischemia and Reperfusion on Skeletal Muscle Damage

[+] Author Affiliations
Sandra Loerakker, Emmy Manders, Gustav J. Strijkers, Frank P. T. Baaijens, Klaas Nicolay, Cees W. J. Oomens

Eindhoven University of Technology, Eindhoven, The Netherlands

Dan L. Bader

Queen Mary, University of London, London, UK

Paper No. SBC2010-19341, pp. 41-42; 2 pages
  • ASME 2010 Summer Bioengineering Conference
  • ASME 2010 Summer Bioengineering Conference, Parts A and B
  • Naples, Florida, USA, June 16–19, 2010
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4403-8
  • Copyright © 2010 by ASME


Sustained mechanical loading of soft tissues covering bony prominences, as experienced by bedridden and wheelchair-bound individuals, may cause skeletal muscle damage. This can result in a condition termed pressure-related deep tissue injury (DTI), a severe kind of pressure ulcer that initiates in deep tissue layers, and progresses towards the skin. Damage pathways leading to DTI can involve ischemia, ischemia/reperfusion injury, impaired lymphatic drainage, and sustained tissue deformation. Recently, we have provided evidence that in a controlled animal model, deformation is the main trigger for damage within a 2h loading period [1,2]. However, ischemia and reperfusion may play a more important role in the damage process during prolonged loading periods.

Copyright © 2010 by ASME
Topics: Muscle



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