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Biomolecule-Impregnated Nanocomposite With Spatiotemporal Control Over Release and Degradation Kinetic for Vascular Engineering

[+] Author Affiliations
Walter Bonani

University of Trento, Trento, ItalyUniversity of Colorado at Boulder, Boulder, CO

Antonella Motta, Claudio Migliaresi

University of Trento, Trento, Italy

Wei Tan

University of Colorado at Boulder, Boulder, COUniversity of Colorado at Denver, Aurora, CO

Paper No. SBC2010-19646, pp. 153-154; 2 pages
doi:10.1115/SBC2010-19646
From:
  • ASME 2010 Summer Bioengineering Conference
  • ASME 2010 Summer Bioengineering Conference, Parts A and B
  • Naples, Florida, USA, June 16–19, 2010
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4403-8
  • Copyright © 2010 by ASME

abstract

Autologous vessels are the gold standard for small-diameter (<6 mm) vascular bypass; however, many patients lack suitable autologous tissues due to diseases or prior vein harvest. As an alternative, synthetic vascular grafts made from bioinert synthetic materials such as polytetrafluoroethylene (PTFE) are currently used in the medical field. The high long-term failure rate of these materials in the replacement of small vessels is known to be associated with the lack of proper signalling events by PTFE to vascular cells causing adverse hemodynamic, inflammatory or coagulatory conditions. Therefore, constant and pressing is the demand for a more biocompatible conduit with structure and function similar to native vessels. For this reason, bioresorbable scaffold constructs which can provide not only proper mechanical support, but also precise molecular cues, are desired (1). In particular, proper degradation kinetics and molecule release profiles are needed to facilitate remodeling and integration process in vivo over the time for long-term patency (2).

Copyright © 2010 by ASME

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