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Nonlinear Osmotic Properties of the Cell Nucleus

[+] Author Affiliations
John D. Finan, Kevin J. Chalut, Adam Wax, Farshid Guilak

Duke University, Durham, NC

Paper No. SBC2009-206197, pp. 93-94; 2 pages
doi:10.1115/SBC2009-206197
From:
  • ASME 2009 Summer Bioengineering Conference
  • ASME 2009 Summer Bioengineering Conference, Parts A and B
  • Lake Tahoe, California, USA, June 17–21, 2009
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4891-3
  • Copyright © 2009 by ASME

abstract

Osmotic stress affects biological function in articular chondrocytes and plays an important role in mechanotransduction in articular cartilage. One potential pathway for osmotic sensitivity in chondrocytes is direct deformation of the nucleus by osmotic stress [1,2]. However, the mechanism of this phenomenon is currently unclear. The nucleus is not contained within a semi-permeable lipid bilayer as are most osmotically sensitive organelles. It is conceivable that fixed charges in chromatin might attract dissolved ions and render it osmotically sensitive. However, this model cannot account for the abolition of the osmotic sensitivity of the nucleus by permeabilization of the cell membrane [3]. The goal of this study was to characterize the osmotic sensitivity of the chondrocyte nucleus and determine the underlying mechanism.

Copyright © 2009 by ASME

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