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Finite Element Modeling of the Tubular Embryonic Chick Heart With Smoothed Surfaces and Contact With Splanchnopleure Membrane

[+] Author Affiliations
Jiang Yao, Jonathan M. Young, Nils Klinkenberg, Jincheng Wang, Renato Perucchio

University of Rochester, Rochester, NY

Benjamen A. Filas, Larry A. Taber

Washington University in St. Louis, St. Louis, MO

Paper No. SBC2009-206466, pp. 707-708; 2 pages
doi:10.1115/SBC2009-206466
From:
  • ASME 2009 Summer Bioengineering Conference
  • ASME 2009 Summer Bioengineering Conference, Parts A and B
  • Lake Tahoe, California, USA, June 17–21, 2009
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4891-3
  • Copyright © 2009 by ASME

abstract

During cardiac development, the initially straight heart tube bends ventrally and rotates towards the right side of the embryo. The biomechanical mechanism of cardiac looping is still unclear, but it has been hypothesized to be related to the unbalanced forces in the left and right omphalomesenteric veins (OVs) generated by cytoskeletal contraction and cell migration, as well as contact with the Splanchnopleure (SPL), a membrane which is located at the ventral surface of the heart and wraps around the OV at the anterior intestinal portal (AIP) [1]. To test this hypothesis, a computational model is a powerful tool. The objective of this study is to generate a finite element model (FEM) with realistic geometry of the tubular heart with the OVs in its caudal ends, which contacts with the SPL. In alternative to the voxel based model, as explored by Young et al. [2], we study issues related to a model with smoothed surfaces, and its capacity in dealing with nonlinear material, large deformation and contact. Although heart looping proceeds normally without pressure generated from heart beat [3], we applied an internal pressure to test the model.

Copyright © 2009 by ASME

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