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Individual Motions of Red Blood Cells in High-Hematocrit Blood Flowing in a Microchannel With Complex Geometries

[+] Author Affiliations
T. Ishikawa, H. Fujiwara, N. Matsuki, Y. Imai, H. Ueno, T. Yamaguchi

Tohoku University, Sendai, Japan

R. Lima

Braganca Polytechnic Inst., Braganca, Portugal

Paper No. SBC2009-206462, pp. 443-444; 2 pages
doi:10.1115/SBC2009-206462
From:
  • ASME 2009 Summer Bioengineering Conference
  • ASME 2009 Summer Bioengineering Conference, Parts A and B
  • Lake Tahoe, California, USA, June 17–21, 2009
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4891-3
  • Copyright © 2009 by ASME

abstract

Blood flow in a microchannel with complex geometries has been investigated to develop biomedical microdevices (e.g. Faivre et al., 2006) or to understand pathology in small vessels, such as lacunar infarcts. In a small channel, say 100 μm in diameter, the blood is no longer assumed to be a homogeneous fluid because the size of the red blood cells (RBCs) cannot be neglected compared to the generated flow field (the diameter of a RBC is about 8 μm). In such a case, we must treat the blood as a multiphase fluid, and investigate the motion of individual cells in discussing the flow field. In this study, we investigated the motion of RBCs in a microchannel with stenosis or bifurcation using a confocal micro-PTV system. We measured individual trajectories of RBCs under high Hct conditions (up to 20%), when the interactions between RBCs become significant. We discuss the effect of Hct on the flow field and cell-free layers, as well as the effect of deformability of RBCs on the cell-free layer thickness by hardening RBCs using a glutaraldehyde treatment.

Copyright © 2009 by ASME

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