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Atherosclerotic Carotid Plaques With Prior Rupture Are Associated With Higher Structural Stresses: In Vivo MRI-Based 3D FSI Studies

[+] Author Affiliations
Zhongzhao Teng, Joseph D. Petruccelli, Xueying Huang, Zijie Liao, Dalin Tang

Worcester Polytechnic Institute, Worcester, MA

Chun Yang

Beijing Normal University, Beijing, China

Chun Yuan, Thomas Hatsukami, Gador Canton, Marina Ferguson

University of Washington, Seattle, WA

Jie Zheng, Pamela K. Woodard

Washington University in St. Louis, St. Louis, MO

Paper No. SBC2009-204708, pp. 169-170; 2 pages
doi:10.1115/SBC2009-204708
From:
  • ASME 2009 Summer Bioengineering Conference
  • ASME 2009 Summer Bioengineering Conference, Parts A and B
  • Lake Tahoe, California, USA, June 17–21, 2009
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4891-3
  • Copyright © 2009 by ASME

abstract

Atherosclerotic plaque vulnerability assessment and the ability to predict possible future rupture are of vital importance for early diagnosis, prevention and treatment of cardiovascular diseases related to atherosclerosis. It has been hypothesized that critical stress conditions in the plaque may be closely related to plaque rupture and can be combined with current image-based assessment techniques for more accurate plaque evaluation. A major challenge for all available plaque assessment schemes is the lack of gold standard based on in vivo patient data where both ruptured and non-ruptured plaques were compared and analyzed. In vivo patient image data showing rupture verified by histological information (current gold standard) provided by excised specimens data will help to establish in vivo benchmark for image-based and/or stress-based assessment schemes.

Copyright © 2009 by ASME

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