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Mechanical Characterization of Fresh Human Carotid Atherosclerotic Plaque

[+] Author Affiliations
Eoghan Maher, Daniel J. Kelly

Trinity College Dublin, Dublin, Ireland

Arthur Creane

Dublin City University, Dublin, Ireland

Sherif Sultan, Niamh Hynes

University College Hospital Galway, Galway, Ireland

Caitríona Lally

Trinity College Dublin, Dublin, IrelandDublin City University, Dublin, Ireland

Paper No. SBC2009-206271, pp. 1307-1308; 2 pages
doi:10.1115/SBC2009-206271
From:
  • ASME 2009 Summer Bioengineering Conference
  • ASME 2009 Summer Bioengineering Conference, Parts A and B
  • Lake Tahoe, California, USA, June 17–21, 2009
  • Conference Sponsors: Bioengineering Division
  • ISBN: 978-0-7918-4891-3
  • Copyright © 2009 by ASME

abstract

Quantifying the properties of atherosclerotic plaques is critical to improving our understanding of the pathogenesis of the disease. Furthermore realistic tissue properties are vital in order to obtain legitimate results from finite element models of surgical interventions used to treat cardiovascular disease. The aim of this study is to determine the mechanical properties of fresh human carotid plaques immediately following removal during endarterectomy. A number of studies have reported atherosclerotic plaque properties previously [1–3], however all of these tested cadaveric tissue. This study will further investigate in-patient and inter-patient variability, the relationship between plaque properties and their clinical classification (calcified, mixed or echolucent) and the location of the sample (common, internal, external carotid).

Copyright © 2009 by ASME
Topics: Atherosclerosis

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