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Modeling Thin-Walled Microbubbles for Medical Ultrasound

[+] Author Affiliations
Kausik Sarkar, Pankaj Jain, Dhiman Chatterjee

University of Delaware

Paper No. IMECE2004-61645, pp. 221-227; 7 pages
doi:10.1115/IMECE2004-61645
From:
  • ASME 2004 International Mechanical Engineering Congress and Exposition
  • Fluids Engineering
  • Anaheim, California, USA, November 13 – 19, 2004
  • Conference Sponsors: Fluids Engineering Division
  • ISBN: 0-7918-4709-8 | eISBN: 0-7918-4178-2, 0-7918-4179-0, 0-7918-4180-4
  • Copyright © 2004 by ASME

abstract

Microbubble contrast agents injected into patient’s body increases contrast of ultrasound images. They are encapsulated by a thin layer of surface active materials to prevent their dissolution inside the body. Here we provide a detail procedure of characterizing them by in vitro acoustic experiment and modeling. The encapsulation is modeled as an interface having an intrinsic surface rheology. The rheological parameters are determined by matching the model with measured attenuation. We have characterized contrast agent Definity with surface tension γ, and dilatational viscosity κs . We also the variation of properties with driving frequency.

Copyright © 2004 by ASME

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