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Comparative Computational Fluid Dynamics and Experimental Phase-Contrast MRI: Evaluations of In-Stent Restenosis

[+] Author Affiliations
Andrea D. Holton, Brigitta C. Brott, Edward G. Walsh, Alan M. Shih, Roy Koomullil, Yasushi Ito, Andreas S. Anayiotos

University of Alabama at Birmingham

Ramakrishna Venugopalan

Codman and Shurtleff

Paper No. IMECE2004-59355, pp. 7-8; 2 pages
  • ASME 2004 International Mechanical Engineering Congress and Exposition
  • Advances in Bioengineering
  • Anaheim, California, USA, November 13 – 19, 2004
  • Conference Sponsors: Bioengineering Division
  • ISBN: 0-7918-4703-9 | eISBN: 0-7918-4178-2, 0-7918-4179-0, 0-7918-4180-4
  • Copyright © 2004 by ASME


While angiography and other translesional catheter-based assessments of stented peripheral vasculature are currently used in clinical applications, a quantitative non-invasive imaging modality would improve the treatment of intermediate levels of in-stent restenosis (ISR). The use of magnetic resonance imaging (MRI), in metal stents has been limited due to magnetic susceptibility artifacts and radiofrequency shielding effects. However, MRI compatible materials such as nickel-titanium alloys used in stents have shown superior lumen visibility. In this study, we used phase contrast MRI in a flow phantom of three different geometries of stenosis: a) 90% axisymmetric, b) 75% axisymmetric and c) 50% asymmetric. The velocity distribution was obtained at 3 different locations inside the stent. This was compared with an equivalent computational fluid dynamics (CFD) model of the same stenotic geometries.

Copyright © 2004 by ASME



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