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Nutrient Transport Within a Tissue Engineered Liver System

[+] Author Affiliations
Robin N. Coger, Sravan Gudi, Mei Niu

University of North Carolina at Charlotte, Charlotte, NC

Paper No. HT-FED2004-56670, pp. 763-764; 2 pages
doi:10.1115/HT-FED2004-56670
From:
  • ASME 2004 Heat Transfer/Fluids Engineering Summer Conference
  • Volume 4
  • Charlotte, North Carolina, USA, July 11–15, 2004
  • Conference Sponsors: Heat Transfer Division and Fluids Engineering Division
  • ISBN: 0-7918-4693-8 | eISBN: 0-7918-3740-8
  • Copyright © 2004 by ASME

abstract

For bioartificial organ devices containing cells packed at high density, establishing suitable nutrient transport pathways is an important engineering challenge. In the case of a tissue engineered liver densely packed with entrapped hepatocytes, the limited transport distance of the nutrient oxygen, restricts the dimensions of the device’s cellular space. This study focuses on improving the functional performance of such devices by enabling enhanced oxygen transport. This enhanced O2 transport is achieved using a technique we developed for increasing the porosity of extracellular matrix (ECM) [1–3]. By combining computational and experimental approaches, the results predict and test the effectiveness of our technique in improving nutrient (e.g., oxygen) flow and cell performance within densely packed liver tissue engineering systems.

Copyright © 2004 by ASME

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