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Growth-Induced Stress Inside Solid Tumor Using Thermoelasticity Model

[+] Author Affiliations
Zhi Zhu He

Chinese Academy of Sciences, Beijing, China

Jing Liu

Tsinghua University, Beijing, China

Paper No. IMECE2011-65745, pp. 707-710; 4 pages
doi:10.1115/IMECE2011-65745
From:
  • ASME 2011 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
  • Denver, Colorado, USA, November 11–17, 2011
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5488-4
  • Copyright © 2011 by ASME

abstract

The tumor growth strongly depends upon the availability of nutrients. Many experimental evidences recently indicated that stress play important role in tumor invasion. The growth-induced stress is from pressure imposed on tumor by surrounding tissues due to tumor expansion invasion. This paper introduces a model to characterize growth-induced stress in solid tumor by analogy with thermoelasticity theory. The model is composed of a nutrients diffusion equation and a stress evolution equation. The solid spheroid tumor stress distribution induced by tumor spatial non-uniformity growth is studied. Moreover, the mechanical interactions between the solid tumor and the surrounding host tissue are discussed detailed.

Copyright © 2011 by ASME

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