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Estimation of Erythrocyte Deformability Using a Viscoelastic Model With Two Degrees of Freedom

[+] Author Affiliations
Tatsuya Mori, Takashi Saito

Yamaguchi University, Ube, Yamaguchi, Japan

Paper No. IMECE2011-63840, pp. 659-663; 5 pages
  • ASME 2011 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
  • Denver, Colorado, USA, November 11–17, 2011
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5488-4
  • Copyright © 2011 by ASME


An erythrocyte is represented using a viscoelastic model with two degrees of freedom, where a spring was connected parallel to a dashpot to estimate quantitatively the dynamic deformability. To identify such parameters as the elastic modulus and viscous damping coefficient of the model, erythrocytes were deformed using a periodical shear flow field. Displacement of the center of gravity ΔG and the deformation quantity of major axis ΔL were obtained from time series of images. In this paper, erythrocytes from a normal subjects were treated with glutaraldehyde to create variations in hardness and deformability. Both of the data series are periodic on movement and deformation of erythrocytes. Based on the experimental data, parameters of the viscoelastic model were identified. The estimation method of dynamic deformability of erythrocytes was examined.

Copyright © 2011 by ASME



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