Full Content is available to subscribers

Subscribe/Learn More  >

Combined Effect of Isoproterenol and Mechanical Oscillation on the Contractile Response of Mice Airway Smooth Muscle

[+] Author Affiliations
M. J. Jo-Avila, A. M. Al-Jumaily, P. Mbikou

Auckland University of Technology, Auckland, New Zealand

L. Sobrevia

Pontificia Universidad Católica de Chile, Santiago, Chile

Paper No. IMECE2011-63163, pp. 651-652; 2 pages
  • ASME 2011 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
  • Denver, Colorado, USA, November 11–17, 2011
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5488-4
  • Copyright © 2011 by ASME


An asthmatic attack is instigated by hyperconstriction of airway smooth muscle (ASM). This can be relieved with bronchodilator medication such as Isoproterenol (ISO). This paper hypothesizes that mechanical oscillations may improve drugs therapy when combined with ISO. Preliminary results indicate that combining ISO with breathing equivalent mechanical oscillations trends to increase the relaxation response as compared with the use of ISO alone. The effect of superposed oscillations in the range of 10–30 Hz of frequency applied over breathing equivalent mechanical oscillations was also assessed in the study.

Copyright © 2011 by ASME
Topics: Oscillations , Muscle



Interactive Graphics


Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In