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Combined Effect of Isoproterenol and Mechanical Oscillation on the Contractile Response of Mice Airway Smooth Muscle

[+] Author Affiliations
M. J. Jo-Avila, A. M. Al-Jumaily, P. Mbikou

Auckland University of Technology, Auckland, New Zealand

L. Sobrevia

Pontificia Universidad Católica de Chile, Santiago, Chile

Paper No. IMECE2011-63163, pp. 651-652; 2 pages
doi:10.1115/IMECE2011-63163
From:
  • ASME 2011 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
  • Denver, Colorado, USA, November 11–17, 2011
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5488-4
  • Copyright © 2011 by ASME

abstract

An asthmatic attack is instigated by hyperconstriction of airway smooth muscle (ASM). This can be relieved with bronchodilator medication such as Isoproterenol (ISO). This paper hypothesizes that mechanical oscillations may improve drugs therapy when combined with ISO. Preliminary results indicate that combining ISO with breathing equivalent mechanical oscillations trends to increase the relaxation response as compared with the use of ISO alone. The effect of superposed oscillations in the range of 10–30 Hz of frequency applied over breathing equivalent mechanical oscillations was also assessed in the study.

Copyright © 2011 by ASME
Topics: Oscillations , Muscle

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