0

Full Content is available to subscribers

Subscribe/Learn More  >

Short-Pulse Laser-Based System for Detection of Tumors: Administration of Gold Nanoparticles Enhances Contrast

[+] Author Affiliations
A. Y. Sajjadi, A. Suratkar, K. Mitra, M. S. Grace

Florida Institute of Technology, Melbourne, FL

Paper No. IMECE2011-64949, pp. 235-240; 6 pages
doi:10.1115/IMECE2011-64949
From:
  • ASME 2011 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
  • Denver, Colorado, USA, November 11–17, 2011
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5488-4
  • Copyright © 2011 by ASME

abstract

The objective of this paper is to demonstrate the use of gold nanoparticles, which accumulate in tumors due to the leakiness of tumor vasculature, as contrast agents for enhanced imaging in a time-resolved optical tomography system using short-pulse lasers for skin cancer detection. Mouse tissue was analyzed in vivo by optical coherence tomography during exposure to the beam of either a 514nm, 200ps pulsed laser or a 776nm, 1.3ps pulsed laser. It was found that addition of spherical gold nanoparticles, either by injection under the skin or by intravenous administration, decreased total reflection intensity and broadened the temporal profile of reflected photons. Together, these results show that gold nanoparticles tuned to the wavelength of the laser can enhance contrast between labeled and unlabeled tissues, and suggest that gold nanoparticles may enhance the sensitivity and resolution of laser-based cancer detection and therapeutic treatment.

Copyright © 2011 by ASME

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In