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Control of Wall Thickness of Blood Vessel Biomodel Made of Poly (Vinyl Alcohol) Hydrogel by a Three-Dimensional-Rotating Spin Dip-Coating Method

[+] Author Affiliations
Hiroyuki Kosukegawa, Chihaya Kiyomitsu, Makoto Ohta

Tohoku University, Sendai, Miyagi, Japan

Paper No. IMECE2011-64619, pp. 221-228; 8 pages
doi:10.1115/IMECE2011-64619
From:
  • ASME 2011 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering; Nanoengineering for Medicine and Biology
  • Denver, Colorado, USA, November 11–17, 2011
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-5488-4
  • Copyright © 2011 by ASME

abstract

To control the thickness of a PVA-H biomodel of human arteries and veins (150 to 800 μm in thickness), a three-dimensional-rotating spin dip-coating apparatus was fabricated. A straight aluminum cylinder (Ra = 0.16 μm) was employed as substrate. Spin dip-coating was carried out in a cooling chamber at 10°C for 1 hour, and then the substrate was quenched at −30°C for gelation of PVA. The thickness of the deposited PVA-H was measured by using a confocal laser displacement meter. Under the experimental conditions employed, PVA-H with a thickness over 30 μm was obtained. The thickness linearly increased with repeated dippings. The thickness of PVA-H depends on the dipping withdrawal speed, the viscosity of the PVA solution, and the diameter of the substrate. Furthermore, the thickness of PVA-H was found to be almost the same when the viscosity of the PVA solution was constant, regardless of the concentrations of PVA. These results indicate that a tube-shaped PVA-H biomodel with desired thickness and physical properties can be obtained by using a spin dip-coating technique and that PVA-H can mimic the wall thickness of various arteries and veins.

Copyright © 2011 by ASME

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