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Tensile Deformation Study on Biological Cells

[+] Author Affiliations
B. A. Samuel, M. A. Haque

The Pennsylvania State University, University Park, PA

Paper No. IMECE2008-67683, pp. 695-697; 3 pages
doi:10.1115/IMECE2008-67683
From:
  • ASME 2008 International Mechanical Engineering Congress and Exposition
  • Volume 2: Biomedical and Biotechnology Engineering
  • Boston, Massachusetts, USA, October 31–November 6, 2008
  • Conference Sponsors: ASME
  • ISBN: 978-0-7918-4863-0 | eISBN: 978-0-7918-3840-2
  • Copyright © 2008 by ASME

abstract

We demonstrate experimental mechanical testing of single live biological cells in-situ under an optical microscope. Tensile loading was the mode of load application and the response of live biological cells were observed in-situ. The experimental set-up is small enough to fit within the stage of a fluorescence microscope. Bovine Aortic Endothelial cells were tested in this study and were found to be able to undergo very large applied strains without loss of cell’s mechanical integrity.

Copyright © 2008 by ASME

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